Num 10:33 So they set out from the mount of the LORD three days’ journey. And the ark of the covenant of the LORD went before them three days’ journey, to seek out a resting place for them. And the cloud of the LORD was over them by day, whenever they set out from the camp. And whenever the ark set out, Moses said, “Arise, O LORD, and let your enemies be scattered, and let those who hate you flee before you.” And when it rested, he said, “Return, O LORD, to the ten thousand thousands of Israel.”
As they begin the journey to the Promised Land, they were guided by God’s presence, not by their own sense of direction. They followed the cloud no matter where God led them. If they were to camp in a rough place, they did it. If they were told to depart from a comfortable place, they did it. They allowed themselves to be guided by God, not by their own wisdom or desire for comfort and ease.
The idea was simple: “God, go before us and take care of our enemies. It’s too dangerous ahead unless You do this.” This is a fitting prayer for every believer to pray, and that faith here displayed gives the sense that Canaan would soon be theirs. (Guzik)
Spurgeon also saw this as a good prayer for the front-line missionary and the one laboring in difficult places: “Are you serving God in some particular work where many are seeking to undo all that you can accomplish? Are you a City Missionary, and do you labour in the midst of a den of iniquity? Does it seem that what you do in one day is undone in one hour by others? Take it to the throne of grace. Say, ‘Rise up, Lord, and let thine enemies be scattered.’” “Will you and I go home and pray this prayer by ourselves, fervently laying hold upon the horns of God’s altar? I charge you, my brethren in Christ, do not neglect this private duty. Go, each one of you, to your chambers; shut your doors; cry to him who hears in secret, and let this be the burden of your cry – ‘Rise up, Lord; and let thine enemies be scattered.’” (Spurgeon)
God is honored and glorified when we trust, rely upon, obey, follow, and humbly serve Him without reservation.